The Belgium international returned to Stamford Bridge over the summer, with Chelsea paying a club-record £97.5m to re-sign the centre-forward.
Lukaku has made an impressive start to life back at the club, finding the back of the net on four occasions in seven appearances, including a goal against Zenit St Petersburg in the Champions League earlier this month.
Chelsea will be keen to return to winning ways on Wednesday, having suffered a 1-0 defeat to Manchester City in the Premier League last time out.
Here, Sports Mole looks at how Lukaku has fared against Juventus in the past.
Lukaku has played against Juventus on six previous occasions, one of which came for Manchester United, as the striker was a part of the side that lost 1-0 at home to the Old Lady in the group stage of the Champions League during the 2018-19 campaign, but he missed the return fixture in Turin due to a muscle issue.
The Belgian faced Juve on five occasions during his time at Inter, meanwhile, four of which came in Serie A, while he also took on the Turin giants in the semi-finals of the Coppa Italia last term.
Lukaku has only been on the winning side on one occasion against the Black and Whites, which came in a Serie A clash in January.
There has also been one draw - the second leg of the Coppa Italia semi-final last season - but the striker has lost four of his six matches against Juve, including three in Serie A with Inter.
Lukaku has only scored once in his six outings against Wednesday's opponents, meanwhile, with his solitary effort coming in a 3-2 defeat for Inter in Turin back in May. body check tags ::