On the other hand, MK Dons head into the fixture on the back of a 2-0 victory, having put together a three-game unbeaten streak in League One.
Jimmy Floyd Hasselbaink will be hoping his squad can pick up their fourth win of the season on Tuesday and respond to the recent 1-1 draw they picked up against Cheltenham Town.
The point was welcomed by Hasselbaink on the back of a 3-0 defeat against Cambridge United in their previous outing, which is why this cup fixture will likely be a positive distraction in a bid to get back to winning ways.
Burton have started the season well though, currently sitting just outside the playoffs in League One, being just two points behind the leaders Sunderland.
With just one defeat so far in the league, there should be no shortage of confidence, although they will be hoping for an improvement on their EFL Cup adventures which saw them knocked out in the first round against Oxford United via penalties.
In a group that also features Wycombe Wanderers and Aston Villa's Under-21s side, both MK Dons and Burton will be hoping to start with a positive result.
Last season saw Burton crash out of the competition in the group stage, finishing third after securing just one victory, meanwhile MK Dons topped their group.
The Dons actually made it through to the quarter-finals last season in the EFL Trophy, eventually being knocked out by Sunderland who then went on to win the entire competition.
Much like Burton, MK Dons have only lost once so far in the league, having drawn twice and picked up two wins as well, one of which took place during their most recent outing.
Manning only took charge of the club partway through August after Russell Martin took over Swansea City, but so far it has been a great start for him, having guided the team to two wins and a draw, with only one defeat to the current league leaders Sunderland.
Last season MK Dons were able to take four points from their fixtures with Burton in the league, but The Dons have yet to secure a victory away from home this season.
After coming off injured against Cheltenham, Burton will be without Mancienne for this cup fixture which will likely provide an opportunity for Bryn Morris to start in the midfield for the first time since suffering a dead leg.
Omari Patrick joined the club in the summer from Carlisle United and he has had the chance to lead the line for Burton, which could be set to continue.
Both Kane Hemmings and Ciaran Gilligan recently returned to first-team training and while this game might be too soon for them to start, there could be a chance for Hasselbaink to name them within the squad.
Manning has guaranteed that he will make changes to his side for this fixture, which will provide opportunities for other members of the squad to get some game time.
Eisa suffered a slight knock during the victory against Accrington and despite scoring in that game, the striker could be rested on Tuesday.
Burton Albion possible starting lineup:
Garratt; Brayford, Shaughnessy, Leak, Hamer; Morris, Borthwick-Jackson; Akins, Powell, Smith; Patrick
MK Dons possible starting lineup:
Ravizzoli; O'Hora, Darling, Lewington; Watson, O'Riley, McEachran, Harvie, Twine, Boateng; Parrott
We say: Burton Albion 2-1 MK Dons
This EFL Trophy fixture brings two teams in great form together, which will no doubt provide a close contest that will be determined by small moments.
However, with Burton having the home advantage and several players potentially returning from injury they might just have enough to edge this particular tie.
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