Coman picked up a hamstring injury on international duty, while Pavard has been suffering with an ankle problem.
There are plenty of attacking options at Julian Nagelsmann's disposal who can fill in for Coman, including Jamal Musiala, Leroy Sane and Serge Gnabry, while 21-year-old Josip Stanisic is expected to keep his place at right-back in Pavard's absence.
Midfielder Corentin Tolisso has recovered from a calf injury and will be in contention to feature at the Red Bull Arena, however Joshua Kimmich and Leon Goretzka are expected to start once again in central midfield.
The Poland international has scored in each of his last 13 Bundesliga games and is just three behind the record set by club legend Gerd Muller, who scored in 16 top-flight matches in a row during the 1969-70 season.
Summer signings Dayot Upamecano and Marcel Sabitzer could be in line to face their former club Leipzig this weekend, though the latter – who is yet to start a game for club or country so far this season – is doubtful with a groin problem.
Bayern Munich possible starting lineup: Neuer; Stanisic, Upamecano, Sule, Davies; Kimmich, Goretzka; Gnabry, Muller, Musiala; Lewandowski
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