The home side have picked up 18 points from their opening 11 matches to sit eighth in the table, while Cadiz have collected nine points from their first 12 fixtures, which has left them in 18th position.
Athletic, alongside Villarreal, have been the draw specialists in La Liga this season, sharing the points in six of their 11 matches, while they have also won four times and lost just once during a solid start.
A total of 18 points has left Marcelino's side in eighth position in the table, just four points behind fourth-placed Atletico Madrid, and the hosts will bring a five-match unbeaten run into Friday's contest.
Athletic travelled to division leaders Real Sociedad in the Basque derby last weekend and looked to be heading for a one-goal loss until Iker Muniain levelled the scores in second-half stoppage time.
The Lions suffered a shock 2-1 home defeat to Rayo Vallecano on September 21, but they have been largely impressive in front of their own supporters this season, holding Barcelona, in addition to beating Mallorca, Alaves and Villarreal.
Athletic suffered a 1-0 home loss to Cadiz in the corresponding clash between the two teams last season, but the Basque outfit ran out 4-0 winners when the pair last locked horns in February.
The Yellow Submarine were so impressive on their return to this level last season, claiming 12th, but they have found it difficult to show their best form in the early stages of the 2021-22 campaign.
A record of one win, six draws and five defeats from 12 matches has seen Cadiz collect nine points, which has left them in 18th position in the table, just three points above basement side Getafe.
Cervera's team have actually scored 11 times in the league this season, which is far from a disastrous record, but they have shipped 19 down the other end, which is the second-worst record in the division behind Levante (23).
Cadiz will be wary of suffering from second-season syndrome in La Liga, but they were impressive in their last away league fixture at the end of October, picking up a point against Villarreal, which should stand them in good stead heading into Friday's encounter at San Mames.
Varazdat Haroyan should also return, having missed out against Mallorca through suspension, while Chapela's absence could see Ruben Sobrino drop into a wide area, with Negredo returning in the final third of the field.
Athletic Bilbao possible starting lineup:
Simon; De Marcos, Yeray, Nunez, Lekue; Berenguer, Vencedor, D Garcia, Muniain; R Garcia, Williams
Cadiz possible starting lineup:
Ledesma; Haroyan, Cala, Chust, Espino; Sobrino, Jonsson, Alex, Perea; Negredo, Lozano
We say: Athletic Bilbao 2-1 Cadiz
Cadiz are capable of making this a difficult assignment for Athletic despite their struggles in the early stages of the campaign. Marcelino's side have been impressive this term, though, and we are expecting the Basque outfit to put another three points on the board at San Mames.
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