The hosts suffered their first defeat of the season just before the international break, leaving Arsenal as the team with the longest ongoing unbeaten streak in the division.
Here, Sports Mole rounds up the team news and injury latest for both clubs.
Out: Roberto Firmino (thigh), Joe Gomez (calf), James Milner (hamstring), Naby Keita (hamstring), Harvey Elliott (ankle), Curtis Jones (eye)
Doubtful: Andrew Robertson (thigh), Sadio Mane (rib), Jordan Henderson (groin), Divock Origi (dead leg)
Sports Mole's predicted XI: Alisson; Alexander-Arnold, Matip, Van Dijk, Robertson; Oxlade-Chamberlain, Fabinho, Thiago; Salah, Jota, Mane
Sports Mole's predicted XI: Ramsdale; Tomiyasu, White, Gabriel, Tierney; Saka, Thomas, Lokonga, Smith Rowe; Lacazette; Aubameyang
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