Aubameyang has lost the trust of Arteta and the captaincy following yet another disciplinary breach, but the Arsenal boss will have a big call to make in the middle with Partey unavailable.
Here, Sports Mole looks at how Arsenal could line up without Aubameyang and Partey during AFCON.
With Aubameyang being frozen out of the team in recent weeks, Arteta's choices in the final third will not be impacted too much, with either Alexandre Lacazette or Gabriel Martinelli spearheading the charge.
Maitland-Niles's man of the match performance against Watford has not helped him reignite his Arsenal career, so Sambi Lokonga may be the preferred option in the middle of the park.
Arteta's backline will not be affected by the AFCON call-ups, with Kieran Tierney, Gabriel, Ben White, Takehiro Tomiyasu and Aaron Ramsdale all set to retain their spots until festive rotation sets in.
Tierney's place on the left is not totally secure given the emergence of Nuno Tavares, but the Scot has won back his rightful place in Arteta's XI after a brief spell on the bench.
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