Genoa vs. Napoli (Sunday, 5.30pm)
While Luciano Spalletti's side were able to overcome an early red card to beat Venezia last week, their hosts were thumped by defending champions Inter Milan at San Siro.
We say: Genoa 0-2 Napoli
Genoa look like a side set to struggle for goals this term, while Napoli are their exact opposite - even without some of their top attacking stars.
The visitors should dominate both the ball and the scoreboard on Sunday, with victory set to send their multinational squad off to the four corners of the globe having sealed maximum points from the first two rounds.
Sassuolo vs. Sampdoria (Sunday, 5.30pm)
While last week the Neroverdi were victorious in Verona, Samp fell to an opening-day defeat against Milan at Marassi.
We say: Sassuolo 2-2 Sampdoria
Sassuolo's current options in the final third would be the envy of several higher-ranked sides above them in the hierarchy, and their talented attackers should ripple the net again on more than one occasion against Sampdoria.
The visitors, though, were unlucky not to open their account against Milan, and their energetic wingers can put the Neroverdi's wandering full-backs to the test.
AC Milan vs. Cagliari (Sunday, 7.45pm)
While the Rossoneri edged out Sampdoria on the opening day, their visitors were held to a disappointing home draw.
We say: AC Milan 1-0 Cagliari
A second one-goal win of the new season is on the cards for Milan, as they are poised to continue their longstanding supremacy over their Sardinian counterparts on Sunday.
If Fikayo Tomori and Simon Kjaer can keep Joao Pedro quiet, then Cagliari can offer little else in attack and are likely to concede at least once over the course of 90 minutes.
Salernitana vs. Roma (Sunday, 7.45pm)
While the Giallorossi carried the momentum of an opening-day win into European competition to seal back-to-back victories, their hosts lost at Bologna on their return to Serie A after 22 years away.
We say: Salernitana 1-3 Roma
While they have proved a formidable force at the Olimpico in recent times, Roma have been far less stable on the road. Nonetheless, they are unbeaten in their last 36 games against newly-promoted sides and are unlikely to relinquish such a record in Salerno.
If danger man Simy can find his feet quickly, the home side are likely to breach the Giallorossi defence, but the visitors have a variety of firepower available to them which Salernitana simply cannot match.