It continued the Bills’ dominance over the Miami side with this a sixth consecutive victory over Dolphins, who lost quarterback Tua Tagovailoa early on to a rib injury.
Devin Singletary’s 46-yard touchdown got the scoring started before Josh Allen found Stefon Diggs which made it 14-0 at the interval.
A sensational 102-yard TD return from Jamal Agnew could not prevent Jacksonville Jaguars suffering another loss, this latest one to Denver Broncos.
Teddy Bridgewater helped Tim Patrick and Noah Fant go over for Broncos to earn a 23-13 win and Las Vegas Raiders can also boast two out of two.
Not even a minor ankle injury could stop Derek Carr pulling the strings for Raiders, who followed up a narrow triumph over Baltimore Ravens with a nine-point victory over Pittsburgh Steelers.
Matt Gay’s 38-yard field goal gave Los Angeles Rams a hard-fought win over Indianapolis Colts despite Kenny Young being ejected.
Young was forced to leave at the end of the third quarter after he appeared to make contact with the referee but Rams edged ahead late on through Cooper Kupp’s TD.
A last-gasp 43-yard field goal gave Washington a 30-29 victory over New York Giants.
Defending Super Bowl champions Tampa Bay Buccaneers routed Atlanta Falcons 48-25. Tom Brady threw for 276 yards and five touchdowns, with the Bucs scoring more than 30 points in a victory for a record ninth successive time.
Greg Joseph missed a last-minute field goal as Minnesota Vikings slipped to a 34-33 loss to Arizona Cardinals while Tennessee Titans recovered a 14-point deficit to stun Seattle Seahawks 33-30.